Roseas venom kills before p murinus venom?Here's some data taken from Escoubas, Pierre & Lachlan Rash. "Tarantulas: eight legged pharmacists and combinatorial chemists." Toxicon 43 (2004): 555-574:
0.1 microliter of crude venom injected intracerebroventricularly (ICV) in mice:
Species - Time to death (min)
Cithariscius crawshayi - 3
Stromatopelma calceatum - 3
Paraphysa sp. - 4
Poecilotheria regalis - 4
Grammostola actaeon - 5
Grammostola rosea - 5
Heteroscodra maculata - 5
Hysterocrates hercules - 5
Theraphosa blondi - 5
Paraphysa scrofa - 6
Pterinochilus murinus - 6
Avicularia urticans - 8
Grammostola pulchra - 8
Selenocosmia lyra - 8
Ceratogyrus meridionalis - 10
Cyclosternum fasciatum - 10
Cyriopagopus paganus - 10
Eucratoscelus constrictus - 10
Haplopelma lividum - 10
Tapinauchenius latipes - 12
Hysterocrates gigas - 15
Megaphobema velvetosoma - 16
Poecilotheria fasciata - 18
Ceratogyrus marshalli - 20
Pamphobeteus antinous - 25
Ceratogyrus brachycephalus - 40
Ephebopus murinus - 45
Brachypelma boehmei - 50
Megaphobema robustum - 50
Aphonopelma anax - 60
Aphonopelma chalcodes - 60
Aphonopelma pallidum - 60
Aphonopelma seemani - 60
Avicularia avicularia - 60
Brachypelma albopilosum - 60
Brachypelma angustum - 60
Brachypelma auratum - 60
Brachypelma emilia - 60
Brachypelma smithi - 60
Brachypelma vagans - 60
Crassicrus lamanai - 60
Lasiodora parahybana - 60
Megaphobema mesomelas - 60
Pamphobeteus vespertinus - 60
Psalmopoeus cambridgei - 60
Tapinauchenius gigas - 60
Vitalius platyomma - 60
In mice, yes it would appear so. That doesn't mean a rosea bite would be worse than an OBT bite in a human. The venom affects different organisms in different ways.Roseas venom kills before p murinus venom?
Codykrr, you're right, but the same can be said about their effect on humans, since not all the tarantulas in the wild have a privilege to bite humans and adapt their venom.^ It has been deemed inaccurate due to the fact not all tarantulas will experience rodents in the wild. Therefore their venom never adapted to killing rodents. This would mean some Genus/species will make a mouse die faster than that of a tarantula who's venom never evolved to target rodents. Which is why scientists do not utilize the LD50 system on tarantulas.
This discussion has been beaten with a stick here many times before. To truly find out what tarantula has the "most potent" venom to humans, we would need a human test subject. plain and simple.
Either way, Im willing to say it would be S. calceatum, or a P. subfusca. The P. subfusca made a guy go into coma off and on for weeks.
No, they dont, now depending on what the EXACT question is IE- "what is the most potent tarantula venom to humans". This is what most people mean when they ask this simple question. But since tarantulas have not adapted there venom to kill humans make us an excellent test subject. Though to be accurate, we would need several test subjects who take administered doses to know how bad the effects vary for each person.Codykrr, you're right, but the same can be said about their effect on humans, since not all the tarantulas in the wild have a privilege to bite humans and adapt their venom.
Again, no it does not. this is apples to oranges. This would be like trying to poison a dog with something that ONLY affects humans and then basing how poisonous it is to birds on that....I'm not implying that the results of the experiment can be blindly applied to humans, but at least it gives us some basic idea on the venom potency.
this is very true. Also this is why we have the LD50 scale. they use it for snakes, scorpions and other things that have venom which does not specifically target the mouse, then apply that to human potency. This is not far off for a lot of things they do test them for. (scorpions mainly come to mind)Here's an excerpt from wikipedia on laboratory mice:
"Mice are common experimental animals in biology and psychology; primarily because they are mammals, are relatively easy to maintain and handle, reproduce quickly, and share a high degree of homology with humans. The mouse genome has been sequenced, and many mouse genes have human homologues."
Keep reading...because of the dozens of pokie bite reports I have read, the P. ornata(robc bite) and the P. subfusca bite in which the man went in and out of coma seemed to be way worse than the P. regalis reports(robc report included)Somewhere I heard that P. regalis was the most venomous of all Pokies. It might have been on here in the bite reports, but I am not sure where so I can not provide a source.